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WARD-TCM: Transcutaneous Monitoring

Accuracy of Transcutaneous Monitoring of Blood Gases in Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease on Non-invasive Ventilation.


Study design:

Observational study

Sample size

20 participants

Study Sites

Rigshospitalet and Bispebjerg Hospital

Inclusion criteria

Adult patients (from 18 years of age) admitted with Acute Exacerbation of Chronic Obstructive Pulmonary Disease (AECOPD) for treatment with non-invasive ventilation or mechanical ventilation. 

Study Procedures

Included patients were monitored after admission to a respiratory intermediate care unit or intensive care unit during ongoing non-invasive ventilation or immediately following extubation. Levels of carbon dioxide and oxygen were monitored using both continuous transcutaneous measurement (TcPCO2 and TcPO2) and simultaneous routine arterial blood gases (PaCO2 and PaO2) for reference. 

Primary outcome

Agreement between transcutaneous monitoring and arterial blood gases calculated as mean bias with 95% limits of agreement for both single point estimates of tcPCO2 vs PaCO2 and tcPO2 vs PaO2, and changes in transcutaneous gases between two timepoints (ΔtcPCO2 and ΔtcPO2).

Primary Investigators

Kasper Mørk Sørensen, Medical student

Rebecca Vienberg, MD

NCT link